2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel

TRP Channel

Transient receptor potential channels

TRP Channel

Related Products

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TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRP channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are initially discovered in trp-mutant strain of the fruit fly Drosophila. Later, TRP channels are found in vertebrates where they are ubiquitously expressed in many cell types and tissues. TRP channels are important for human health as mutations in at least four TRP channels underlie disease.

TRP Channel Isoform Specific Products:

TRP Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-170652
    ZQMT-10
    		Inhibitor
    ZQMT-10 is an orally active and potent antagonist of TRPA1, with the Kd of 1.04 μM. ZQMT-10 plays an important role in cancer research.
    ZQMT-10
  • HY-160509
    BTB 06061
    		Inhibitor
    BTB 06061 is a TRPM7 inhibitor and can be used for study of ischemic disease.
    BTB 06061
  • HY-N0361R
    Dihydrocapsaicin (Standard)
    		Agonist
    Dihydrocapsaicin (Standard) is the analytical standard of Dihydrocapsaicin. This product is intended for research and analytical applications. Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat.
    Dihydrocapsaicin (Standard)
  • HY-P3702
    CEDAEVFKDSMVPGEK
    CEDAEVFKDSMVPGEK is the rat vanilloid receptor subtype 1 (VR1) peptides sequence, can be used to determine the presence and distribution of VR1.
    CEDAEVFKDSMVPGEK
  • HY-161273
    TRPV1 antagonist 6
    		Antagonist
    TRPV1 antagonist 6 (compound 51) is a mode-selective antagonist for transient receptor potential vanilloid member 1 (TRPV1), which shows antagonism with IC50 of 2.85 nM to capsaicin activation and 28.48 % inhibition against proton activation at a 3 µM concentration.
    TRPV1 antagonist 6
  • HY-W517163
    MK-2295
    		Antagonist
    MK-2295 (NGD-8243) is a TRPV1 antagonist. MK-2295 is an analgesic agent, and can be used for research of pain.
    MK-2295
  • HY-30234
    Clemizole
    		Inhibitor
    Clemizole is an H1 histamine receptor antagonist, is found to substantially inhibit HCV replication. Clemizole is an inhibitor of TRPC5 channel. The IC50 of Clemizole for RNA binding by NS4B is 24±1 nM, whereas its EC50 for viral replication is 8 µM.
    Clemizole
  • HY-N10756
    Hyp9
    		Agonist
    Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI).
    Hyp9
  • HY-134261
    8-Br-ADPR
    8-Br-ADPR (8-Bromoadenosine-5'-O-diphosphoribose), an analogue of Adenosine 5′-diphosphoribose (HY-100973), is a TRPM2 modulator. 8-Br-ADPR is a human TRPM2 (hsTRPM2) inhibitor and a Nematostella vectensis (nvTRPM2) partial agonist (EC50 of 31.9 µM). 8-Br-ADPR regulates calcium release from the endoplasmic reticulum and sarcoplasmic reticulum.
    8-Br-ADPR
  • HY-144208
    TRPC5-IN-3
    		Inhibitor
    TRPC5-IN-3 is a potent TRPC5 inhibitor with IC50 of 10.75 nM (WO2022001767A1, L001).
    TRPC5-IN-3
  • HY-114630
    Protokylol
    		Agonist
    Protokylol (Caytine; JB-251) is a beta-adrenergic receptor agonist and TRPV1 agonist. Protokylol is used as a bronchodilator.
    Protokylol
  • HY-N1378R
    (E)-Cardamonin (Standard)
    		Antagonist
    (E)-Cardamonin (Standard) is the analytical standard of (E)-Cardamonin. This product is intended for research and analytical applications. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
    (E)-Cardamonin (Standard)
  • HY-161420
    TRPV1 antagonist 7
    		Antagonist
    TRPV1 antagonist 7 (Compound 36) is a selective TRPV1 antagonist that effectively blocks capsaicin activation (IC50=2.31 nM). TRPV1 antagonist 7 can be used in analgesic research.
    TRPV1 antagonist 7
  • HY-115877
    GDC-0334
    		Antagonist
    GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma.
    GDC-0334
  • HY-116330
    Hyperforin
    		Activator
    Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
    Hyperforin
  • HY-149999
    Xeniafaraunol A
    		Inhibitor
    Xeniafaraunol A (compound 31) is a potent transient receptor potential melastatin 7 (TRPM7) inhibitor.
    Xeniafaraunol A
  • HY-124382
    AS1928370
    AS1928370 is a novel and central nervous system (CNS) penetrant TRPV1 antagonist and can prevent ligand-induced activation in vivo. AS1928370 is a promising agent for neuropathic pain treatment research.
    AS1928370
  • HY-124073
    Dihydrocapsiate
    		Agonist 99.18%
    Dihydrocapsiate, as a compound of capsinoid family, is an orally active TRPV1 agonist. Dihydrocapsiate can be used for the research of metabolism disease.
    Dihydrocapsiate
  • HY-162908
    TRPV1/CB2 agonist 1
    		Agonist
    TRPV1/CB2 agonist 1 (compound 41) is a TRPV1/CB2 agonist, with an EC50 of 26.8 μM for hTRPV1. TRPV1/CB2 agonist 1 can be used in nervous system related research.
    TRPV1/CB2 agonist 1
  • HY-111218
    TRPV1 antagonist 5
    		Antagonist
    TRPV1 antagonist 5 (compound 1) is a potent TRPV1 antagonist.
    TRPV1 antagonist 5
Cat. No. Product Name / Synonyms Application Reactivity
TRP Channel Isoform Comparison

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